Work

Primate embryoids: an in vitro model leading from a totipotency-like phase to early organogenesis

Year: 2026

Type: article

Abstract: In a recent seminal study published in Cell , Zheng et al. 1 demonstrated a sophisticated embryoid model for primate embryogenesis to study development up to early organogenesis in vitro. This embryoid model is based on a totipotent-like cynomolgus blastomere-like stem cell (cTBLC) culture, which can be triggered to autonomously undergo pre- and post-implantation developmental features in a sequential manner reminiscent of these stages after fertilization.

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-026-03003-w

Authors: Aseem Tara, Wilfried A. Kues

Institution: Friedrich-Loeffler-Institut

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,790

Funder: Bill and Melinda Gates Foundation