Year: 2026
Type: article
Study design: Case Report
Abstract: Stevens-Johnson Syndrome (SJS) is a severe mucocutaneous reaction that can lead to chronic ophthalmological complications, compromising the ocular surface and visual prognosis. This paper aims to report the case of a patient with SJS and severe ocular involvement, followed up at an ophthalmological clinic. A 41-year-old male patient had a history of corneal transplantation in the right eye (OD) performed during adolescence. Subsequently, he underwent penetrating retransplantation, complicated by perforation, requiring tectonic transplantation. After a new perforation, corneal patch coverage was performed. Clinical evaluation identified graft thinning and bulging, 360° corneal neovascularization, and bilateral inferior temporal symblepharon. The OD progressed to phthisis bulbi. In the left eye, stromal opacities, keratitis, edema, and symblepharon were observed. Treatment included lubricants, topical antibiotics and corticosteroids, in addition to oral doxycycline. Although evisceration of the right eye (OD) was considered, preservation was chosen as long as the patch remained intact and asymptomatic. This case highlights the difficulty in managing ocular SJS, in which limbal insufficiency and chronic inflammation contribute to graft failure and recurrent perforations. It is concluded that these patients require multidisciplinary follow-up, rigorous inflammatory control, and individualized strategies to preserve ocular integrity and reduce complications.
Source: Revista fisio&terapia.
DOI: 10.69849/jywnkx36
Authors: Rogério Luiz dos Santos Freitas, Carlos Dhiego Gomes de Carvalho, Paulo Thiago Gomes da Silva, Rebeca Carvalho Valença, Maria Júlia Brayner Cavalcanti de Mendonça, Carlos Eduardo Marinho Mesquita, Bruno Pinheiro de Oliveira, José Henrique Diniz Pinheiro Nogueira, João Felipe Mendonça de Azevedo Mello, Anamaria Coutinho Pessoa
Institution: Universidade Católica de Pernambuco
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7224734913