Work

Synthetic Studies on Leptolyngbyalides A–C: Stereoselective Synthesis of the C16–C27 Fragment

Year: 2026

Type: article

Abstract: Leptolyngbyalides A–C, isolated from the cyanobacterium Leptolyngbya sp. PCC 7375, are complex polyol macrolides, which are structurally relevant to oscillariolide and phormidolides A–C. We describe herein a stereoselective synthesis of the C16–C27 fragment of leptolyngbyalides, which involved an Evans syn-aldol reaction, a Kiyooka aldol reaction, and a Mukaiyama aldol reaction to construct the carbon chain with simultaneous generation of the stereogenic centers with full stereocontrol.

Source: Chemistry Letters

DOI: 10.1093/chemle/upag211

Authors: Yuuki Okamura, Naoki Fukaya, Keisuke Murata, Tomoki Tsuruta, Haruhiko Fuwa

Institution: Chuo University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $1,003

OpenAlex ID: W7224744864