Work

Clinical characteristics, management, and outcomes of adults admitted to participating Japanese intensive care units with registry-identified anaphylactic shock: a multicenter retrospective descriptive study

Year: 2026

Type: article

Abstract: Background Anaphylactic shock is an uncommon reason for admission to an intensive care unit (ICU). Existing multicenter Japanese data have focused on perioperative anaphylaxis, and the cross-setting Japanese ICU population has not been described. We aimed to describe such admissions, including those arriving from wards and the emergency department, in a voluntary multicenter Japanese registry. Methods This retrospective study used the Japanese Intensive Care Patient Database (JIPAD), a voluntary registry of participating Japanese ICUs; the unit of analysis was the ICU admission. Eligible records were admissions of patients aged 18 years or older between 1 April 2015 and 31 March 2024 (fiscal years 2015–2023) whose mandatory clinician-entered diagnosis text contained the Japanese stems for both “anaphylaxis” and “shock”; ICU readmissions were excluded. The descriptive cohort comprised 643 admissions; 632 admitted from the operating room, ward, or emergency department formed a route-stratified subset. Results Among 643 admissions, 62 (9.6%) followed cardiac arrest, and a continuous vasoactive infusion was recorded in 234 of the 558 admissions with the relevant fields available (41.9%). All-cause ICU mortality was 1.6% (10/643; 95% confidence interval [CI] 0.8–2.8) and all-cause index-hospital mortality 3.3% (21/643; 95% CI 2.1–4.9); 11 of these 21 deaths occurred after discharge alive from the ICU. Sixty-five admissions (10.1%) ended in transfer alive, with later outcomes unavailable. Conclusions Among ICU admissions with a registry diagnosis of anaphylactic shock at participating Japanese facilities, all-cause ICU mortality was lower than all-cause index-hospital mortality, and more than half of the index-hospital deaths occurred after ICU discharge. Causes of death were unavailable, so these deaths could not be attributed specifically to anaphylaxis.

Source: Journal of Anesthesia Analgesia and Critical Care

DOI: 10.1186/s44158-026-00464-x

Authors: Takaya Nakashima, Motohiro Sekino, Hiroshi Araki, Taiga Ichinomiya, Tetsuya Hara

Institutions: Nagasaki University Hospital, Nagasaki University, Saga University

Language: English

Topic: Food Allergy and Anaphylaxis Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,079