Simultaneous pigmented villonodular synovitis and synovial chondromatosis of the knee joint: case report
Year: 2026
Type: article
Study design: Case Report
Abstract: Background: Pigmented villonodular synovitis (PVNS) and synovial chondromatosis (SC) are rare joint diseases. Their coexistence within the same joint is exceedingly rare, and understanding such overlapping joint pathologies is crucial for improving diagnosis and treatment strategies. Materials and methods: This case has been reported in accordance with the SCARE criteria. A patient presenting with knee pain and swelling underwent arthroscopic examination. Arthroscopic findings suggested the presence of both PVNS and SC. To confirm the diagnosis, post-operative histopathological analysis was performed on synovial tissue samples obtained during arthroscopy. Results: Histopathological examination confirmed the simultaneous presence of PVNS and SC in the knee joint. To our knowledge, this is the first reported case of these two conditions coexisting within an adult knee joint. Arthroscopic examination provided key visual findings that guided the collection of samples, while histopathology validated the overlapping diagnoses. Conclusion: We report a detailed case of simultaneous PVNS and SC in an adult knee joint. The affected synovium and loose bodies were removed arthroscopically, although long-term follow-up is still required. In summary, this case provides valuable clinical insight into a rare presentation, while the underlying cellular and molecular mechanisms warrant further investigation.
Authors: Ping Zhou, Aimin Wang
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,090
OpenAlex ID: W7224816549