Malignant histiocytic neoplasm with dendritic differentiation via transdifferentiation of B-cell lymphoma
Year: 2026
Type: article
Study design: Case Report
Abstract: Follicular lymphoma commonly transforms into diffuse large B-cell lymphoma; however, transdifferentiation into histiocytic/dendritic neoplasms is exceptionally rare. We describe an older male with follicular lymphoma that transformed into high-grade B-cell lymphoma with MYC, BCL2 and BCL6 rearrangements, followed by development of a malignant histiocytic neoplasm with dendritic differentiation involving the liver. Shared molecular findings supported transdifferentiation from the original lymphoma clone. While the malignant histiocytic neoplasm showed a complete response to imatinib, the clinical course was complicated by relapsed high-grade B-cell lymphoma and the patient eventually succumbed to infectious complications.
Source: BMJ Case Reports
Authors: Chao Wu, Wei Cui, Aung M Tun
Institution: University of Kansas Medical Center
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7224863489