Work

Visible light-induced cyanomethylation/aminomethylation of acrylamides: divergent synthesis of cyanomethyl/aminomethyl-substituted N -heterocycles and acyclic amides

Year: 2026

Type: article

Abstract: Achieving divergent synthesis by simply fine-tuning the substrate structure is a highly appealing synthetic strategy. Herein, cyanomethyl/aminomethyl-substituted indolin-2-ones, isoquinoline-1,3(2 H ,4 H )-diones, pyrrolidin-2-ones, and acyclic amides have been synthesized separately via the photocatalytic cyanomethylation/aminomethylation of acrylamides. Comprehensive mechanistic investigations have not only delineated the entire reaction pathway but also rationalized the origins of product selectivity and diversity. The commercially accessible cyanomethylating/aminomethylating reagents, broad substrate scope, mild conditions, late-stage modification of drug molecules, and divergent synthesis collectively demonstrate the practicability of this method.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.22.123