4-[(4-Fluorophenyl)amino]-5-(2-methoxyphenyl)-8,8-dimethyl-6,7,8,9-tetrahydro-5 H -chromeno[2,3- d ]pyrimidin-6-one
Year: 2026
Type: article
Abstract: The asymmetric unit of the title compound, C 26 H 24 FN 3 O 3 , contains one molecule comprising a tricyclic chromeno[2,3- d ]pyrimidine core formed by fused cyclohexanone, pyran and pyrimidine rings. The sp 3 -hybridized methine carbon atom bears a 2-methoxyphenyl substituent, which is oriented almost perpendicular to the pyran ring, with a dihedral angle of 84.11 (5)°. The 4-fluorophenylamino substituent is twisted relative to the pyrimidine ring, as indicated by the C—C—N—C torsion angle of 29.79 (18)° and the dihedral angle of 27.59 (4)° In the crystal, C—H...O and C—H...F hydrogen bonds link the molecules into supramolecular chains extending diagonally within the ac plane. An intramolecular N—H...O hydrogen bond is also present between the amino and methoxy groups.
Source: IUCrData
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $300
OpenAlex ID: W7224875590