Work

KO t Bu‐Catalyzed Construction of Fully Substituted Phosphate Ester‐Functionalized 5‐Thioureido‐Triazoles

Year: 2026

Type: article

Abstract: ABSTRACT A transition‐metal‐free KO t Bu‐catalyzed three‐component reaction has been established, involving various nitriles, azides, and phosphoroisothiocyanatidates, enabling the construction of fully substituted phosphate ester‐functionalized 5‐thioureido‐triazoles. In this process, nitriles undergo cycloaddition with azides in the presence of a base and the resulting triazolamine and triazole nitrogen anion intermediates subsequently captured by the phosphoroisothiocyanatidate. This protocol is characterized by being transition‐metal‐free, a broad substrate scope, high regioselectivity, and compatibility with late‐stage functionalization.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.70584

Authors: Qinyu Li, Yanqin Wang, Zhihao Zuo, Weiguo Wang

Institution: Qufu Normal University

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Natural Science Foundation of Shandong Province

Award: G2340981969