Evaluation of ACEI Use on Kidney Function and Lipid Profile in Outpatient Hypertension Patients at Raden Mattaher General Hospital, Jambi, Jambi Province
Year: 2026
Type: article
Study design: Observational Study
Abstract: Hypertension is a global health problem that increases the risk of cardiovascular disease and impaired kidney function. The use of Angiotensin-Converting Enzyme Inhibitors (ACEIs) is widely recommended due to their effectiveness in lowering blood pressure and providing renoprotective effects. However, variations in therapeutic responses, particularly in kidney function and lipid profile, require further evaluation. This study aimed to analyze the association between ACEI use and kidney function and lipid profile in outpatient hypertensive patients. This study employed an observational analytic design with a retrospective approach based on medical record data of hypertensive patients receiving ACEI therapy. Samples were selected based on inclusion criteria, with complete data on kidney function (eGFR, serum creatinine, and BUN) and lipid profile (total cholesterol, LDL, HDL, and triglycerides). Data were analyzed using descriptive statistics and inferential analysis using the Kruskal–Wallis test. The results showed that the majority of patients were in the late elderly age group (56–65 years) (39.6%) and predominantly male (62.1%). significantly associated with serum creatinine (p = 0.000), while no significant associations were found with eGFR (p = 0.206) and BUN (p = 0.170). In addition, the duration of ACEI use showed no significant association with eGFR (p = 0.089), but was significantly associated with serum creatinine (p = 0.001) and BUN (p = 0.009). Regarding lipid profiles, both the type and duration of ACEI use were significantly associated with all parameters, including total cholesterol, LDL, HDL, and triglycerides (all p = 0.000). In conclusion, ACEI therapy shows differential associations with kidney function and lipid profile parameters in hypertensive patients. Therefore, regular monitoring of renal function and lipid profiles is recommended to optimize therapeutic outcomes and prevent potential metabolic and renal complications.
Source: JURNAL FARMASIMED (JFM)
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7224910150