Work

Clinical cases and a practical approach to cancer-associated thrombosis and cardiovascular complications: risk assessment, pathophysiology, and therapeutic options

Year: 2026

Type: article

Abstract: Cancer-associated thrombotic complications are common in oncological patients and often proceed with signiﬁcant complications, leading to increased morbidity and mortality. They are the result of a complex interaction between tumor-speciﬁc factors, individual patient characteristics, and the type of oncological treatment. This review examines the epidemiology, risk factors, and the main pathophysiological mechanisms of cancer-associated thrombosis, and presents validated screening systems for thrombotic risk assessment such as the Khorana score and COMPASS-CAT. Contemporary strategies for primary and secondary thromboprophylaxis are discussed, including the role of low-molecular-weight heparins and direct oral anticoagulants. The review is complemented by clinical cases from our practice, illustrating the diagnostic and therapeutic challenges of cancer-associated thrombosis and its related cardiovascular complications.

Source: Bulgarian Cardiology

DOI: 10.3897/bgcardio.32.e186566

Authors: B. Krastev, N. Spasova, D. Somleva, A. Borizanova, P. Kalaydzhiev, D. Markov, E. Kinova, A. Goudev

Institutions: Queen Giovanna Hospital, Medical University of Sofia

Language: English

Topic: Venous Thromboembolism Diagnosis and Management

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7224914097

FWCI:

Cites: 33

Cited by:

Related to: 10