Work

Photoinduced Phosphinylation/Cyclization of 1,5‐Enenitriles for the Synthesis of Phosphinylated Pyrrolidine‐2,4‐diones

Year: 2026

Type: article

Abstract: ABSTRACT A metal‐free blue‐light‐induced radical cascade cyclization of N ‐tethered 1,5‐enenitriles with diarylphosphine oxides for the synthesis of phosphinylated pyrrolidine‐2,4‐diones is described. The transformation tolerates various functional groups and is scalable to gram scale. Radical‐trapping experiments confirm phosphorus‐centered‐radical‐mediated reactivity. Two unreported minor phosphorus‐containing products were detected by LCMS. This work provides a facile photochemical entry to phosphorus‐functionalized pyrrolidine‐2,4‐diones.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.70579

Authors: Zenghui Du, Mifei Yu, Yinchen Zhou, Xiaoming Ma, Jiefa Shen, Jia‐Yin Wang

Institution: Changzhou University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W7224927918

FWCI:

Cites: 44

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Related to: 10