Work

Factors for Favorable Outcomes After Sialendoscopy for Radioactive Iodine‐Induced Sialadenitis of Parotid Gland: An Exploratory Study Toward a Phenotypic Patterns

Year: 2026

Type: article

Abstract: BACKGROUND: Radioactive iodine (RAI) therapy can induce radioactive iodine-induced sialadenitis (RAIS). Sialendoscopy is an effective treatment for RAIS, but predictors of favorable outcomes remain poorly defined. This study aimed to identify functional and anatomical factors associated with favorable outcomes following sialendoscopy in RAIS patients. METHODS: We retrospectively reviewed 44 cases who underwent sialendoscopy for RAIS. Favorable outcome was defined as a symptom resolution without the need for additional medication or revision surgery. RESULTS: In the multivariate model, ΔSFR(pre) (difference between stimulated and unstimulated preoperative SFR) (p = 0.035), symptom duration (p = 0.039), and distal stenosis (p = 0.024) were confirmed as predictors. ROC curve analysis determined the optimal cutoffs for the two continuous independent predictors: low ΔSFR(pre) < 0.41, early intervention < 4.5 months. CONCLUSIONS: This study identified low ΔSFR(pre), early intervention, and distal stenosis of Stenson's duct as associated with favorable outcome.

Source: Head & Neck

DOI: 10.1002/hed.70527

Authors: Sungryeal Kim, Marn Joon Park, Ji Won Kim

Institutions: Ajou University, Inha University Hospital, University of Ulsan, Ulsan University Hospital

Language: English

Topic: Salivary Gland Disorders and Functions

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7224995796

FWCI:

Cites: 15

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Related to: 10