Work

Discovery of 7-Aminofuro[2,3- c ]pyridine-Based Irreversible Inhibitors of TGFβ-Activated Kinase 1 (TAK1) with In Vivo Antitumor Activity

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.6c01364

Authors: Yingying Zuo, Tiancheng Fu, Xuan Chen, Fengli He, Xingwei Chen, Lars Wortmann, Volker K. Schulze, Tobias Kerst Heinrich, Detlev Suelzle, Franz v. Nussbaum, Zhengying Pan

Institutions: Peking University, Bayer (Germany)

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Bayer, National Natural Science Foundation of China, Peking University, Basic and Applied Basic Research Foundation of Guangdong Province

OpenAlex ID: W7225006147

FWCI:

Cites: 39

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Related to: 10