Work

Expanding synthetic lethality through computationally designed aptamers

Year: 2026

Type: article

Abstract: Aptamers are emerging as versatile tools in cancer research and therapy because they combine high target specificity with low immunogenicity, chemical tractability, and straightforward sequence optimization. They have been developed for tumor recognition, biomarker detection, targeted delivery of drugs and therapeutic RNAs, and direct modulation of oncogenic or immune pathways.1,2 Their programmable nature also creates opportunities to target intracellular protein interactions that remain largely inaccessible to conventional therapeutics.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2026.103148

Authors: Giulia Milordini, Elsa Zacco, Gian Gaetano Tartaglia

Institution: Italian Institute of Technology

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900