Identifying Iron Deficiency and Opportunities for IV Iron Supplementation in Patients with Heart Failure with Reduced Ejection Fraction: A Retrospective Cohort Study.
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: In the AFFIRM-AHF trial, IV administration of iron reduced total hospitalizations due to heart failure in patients with acute heart failure and iron deficiency. Objectives: To identify what proportion of patients with heart failure with reduced ejection fraction (HFrEF) had iron deficiency and to compare their rate of hospitalization due to heart failure with that of patients in the AFFIRM-AHF trial. Methods: This retrospective cohort study involved patients with HFrEF seen at a specialized heart failure clinic. Data were collected between February 2021 and August 2022. The primary outcome was the proportion of patients with iron deficiency, with comparison of the rate of hospitalization due to heart failure in this study relative to the AFFIRM-AHF trial. Results: A total of 284 patients were screened to generate the pre-specified sample of 100. Of these, 73% had iron deficiency. After clinic attachment, the rate of hospitalization due to heart failure among patients with iron deficiency was 21.6 per 100 patient-years, compared with 43.2 in the AFFIRM-AHF trial. Conclusions: Although more than two-thirds of patients with HFrEF in the study clinic had iron deficiency, their rate of hospitalization due to heart failure was markedly lower than that reported in the AFFIRM-AHF trial. Therefore, the need for routine IV iron repletion in these patients is questionable.
Source: PubMed
DOI: 10.4212/cjhp.3913
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225048357