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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Mimicking Tuberculous Meningitis Following Epstein-Barr Virus Infection

Year: 2026

Type: article

Abstract: A 49-year-old man with fever, progressive encephalopathy, lymphocytic pleocytosis, rising cerebrospinal fluid adenosine deaminase, Epstein-Barr virus DNA detection, and multifocal cerebral vasospasm was suspected of infectious or tuberculous meningitis, but repeated negative tests for tuberculosis and other pathogens and cerebrospinal fluid anti-glial fibrillary acidic protein (GFAP) antibody positivity established autoimmune GFAP astrocytopathy, which improved after methylprednisolone pulse therapy and plasma exchange.

Source: Journal of the Korean Neurological Association

DOI: 10.17340/jkna.2026.0033

Authors: Sua Park, Inyoung Lee, Chan-Nyoung Lee, Hayom Kim

Institution: Korea University Anam Hospital

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7225050286