Work

Probing the binding dynamics of a sunitinib analog with human serum albumin: a combined spectroscopic and molecular docking approach

Year: 2026

Type: article

Abstract: van der Waals forces and H-bonding interactions. The findings of the ligand-competitive displacement experiment indicate that SA exhibits an affinity for HSA within the subdomain IIIA binding pocket. Analysis of data collected by multiple spectroscopic techniques revealed that SA induces perturbation in the secondary structure of HSA and modifies the polarity of the microenvironment surrounding tryptophan residues.

Source: RSC Advances

DOI: 10.1039/d6ra07888e

Authors: Sohaila A. Abbas, Eman A. Mostafa, Alshaimaa M. Alian, Ehab F. Elkady, Marwa A. Fouad

Institutions: Egyptian Drug Authority, Cairo University, Al Baha University, New Giza University

Language: English

Topic: Protein Interaction Studies and Fluorescence Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,042

OpenAlex ID: W7225074835