Work

Pd-catalyzed, oxidant-promoted, chelation-assisted, regioselective direct ortho -nitration of 1-aryl-1 H -indazoles via C–H bond activation: direct access to novel indazole-based antiproliferative agents

Year: 2026

Type: article

Abstract: Herein, we developed a highly efficient palladium-catalyzed, oxidant-promoted, chelation-assisted, regioselective strategy to introduce the nitro group directly at the ortho -position of the pendant aryl ring of the 1-aryl-1 H -indazoles.

Source: RSC Advances

DOI: 10.1039/d6ra08657h

Authors: Janmejaya Sen, Shivani, Pushpendra Kumar, Ashok Kumar Datusalia, Sandeep Chaudhary

Institutions: National Institute of Pharmaceutical Education and Research, National Institute of Pharmaceutical Education and Research

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

OpenAlex ID: W7225076306

FWCI:

Cites: 34

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Related to: 10