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Electrochemical Allylic Functionalization: A Sustainable Platform for Upgrading Allylic Compounds

Year: 2026

Type: article

Abstract: The upgrading of readily available allylic compounds into functionalized allylic scaffolds is of paramount importance in synthetic chemistry, given their prevalence in drug molecules and their derivatization potential. In this context, electrochemical allylic functionalization emerges as a sustainable platform for this purpose, and constructs CC and C–heteroatom bonds under mild conditions. To date, however, no comprehensive review has specifically addressed this emerging area. In this review, we summarize recent major advances in electrochemical allylic functionalizations, categorized by reaction type into five classes: allylic carboxylation, allylic (hetero)arylation, allylic alkylation, allylic borylation, and allylic CH functionalization. We place particular emphasis on reaction mechanisms and substrate scope, and also discuss the limitations of the reported examples. Finally, we outline current challenges and provide an outlook on future directions, with the aim of inspiring further exciting developments in this rapidly growing area.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70842

Authors: Fei Lian, Zhoumei Tan, Kun Xu

Institutions: Pingdingshan University, Chongqing University of Education, Beijing University of Technology

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

OpenAlex ID: W7225079679

FWCI:

Cites: 88

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Related to: 10