Work

Flow synthesis of polysubstituted pyrroles via a Vilsmeier–chloroacrolein strategy

Year: 2026

Type: article

Abstract: Continuous flow strategy enables rapid synthesis of polysubstituted pyrroles via chloroacrolein, giving higher yields, shorter reaction times, much lower solvent use, and a formal synthesis of lukianol A and lamellarin natural product intermediates.

Source: RSC Advances

DOI: 10.1039/d6ra08430c

Authors: Kingsley Dwomoh, Evelyn Ramirez, Felix Minami, Carlos Perez Mandry, Ariana Kim, Edward Chandler, Joe West, Daniel Fisher, Raymond N. Dominey, Emma W. Goldman

Institution: University of Richmond

Language: English

Topic: Synthesis and Characterization of Pyrroles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: Boehringer Ingelheim, University of Richmond

OpenAlex ID: W7225080637

FWCI:

Cites: 26

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Related to: 10