Get started
Work

Dengue vaccine suspension: clarifying safety signals while strengthening flavivirus vaccine confidence

Year: 2026
Type: article
Abstract: Brazil's temporary suspension of the Butantan dengue vaccine after suspected serious adverse events should be interpreted neither as a failure of dengue vaccination nor as a definitive judgement on the product's safety.1 It is a timely reminder that pharmacovigilance is an active component of vaccine implementation, especially for live-attenuated flavivirus vaccines used in populations with heterogeneous baseline immunity, shifting serotype circulation, and previous exposure to related viruses. A safety signal is not causality.
DOI: 10.1016/j.lana.2026.101663
Institutions: Faculdade de Medicina de São José do Rio Preto, Hospital de Base, The University of Texas Medical Branch at Galveston, Drugs for Neglected Diseases Initiative, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $4,930
OpenAlex ID: W7225083833
FWCI:
Cites: 10
Cited by:
Related to: 10