Work

Multifunctional bio-derived hydrogel loaded with ADSCs for promoting diabetic wound healing

Year: 2026

Type: article

Abstract: Adipose-derived stem cells (ADSCs) hold substantial therapeutic potential for diabetic foot ulcers (DFUs). However, their efficacy is often limited by poor survival within the harsh microenvironment of chronic wounds. In this study, we developed a multifunctional bio-derived hydrogel composed of gelatin methacrylate (GelMA), glycyrrhizic acid (GA), and ferrous ions (Fe 2+ ) that integrates ADSCs with local microenvironment modulation. This approach targets key pathological challenges in DFUs treatment, including persistent inflammation, impaired angiogenesis, and oxidative stress. The hydrogel demonstrated potent antibacterial, antioxidant, and pro-angiogenic activities. Moreover, it significantly accelerated diabetic wound healing, enhanced re-epithelialization and collagen deposition, and promoted macrophage polarization toward the reparative M2 phenotype, thereby effectively improving the wound microenvironment. These results indicate that the GelMA/GA/Fe@ADSCs hydrogel is a promising regenerative therapy with strong translational potential for DFUs and other chronic wounds.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2026.103803