Work

SWI/SNF chromatin remodeling complexes in metabolic disorders: integrating tissue-specific epigenetic mechanisms

Year: 2026

Type: review

Abstract: Metabolic disorders are increasingly linked to epigenetic alterations. SWI/SNF chromatin remodeling complexes have emerged as critical modulators of metabolic homeostasis. In this review, we focus on the tissue-specific biological function of SWI/SNF complexes in the pancreas, liver, adipose tissue, and heart, and highlight the dysregulation of chromatin remodeling in metabolic disease progression. Lastly, we discuss therapeutic opportunities targeting chromatin remodeling mechanisms in metabolic disorders.

Source: npj Metabolic Health and Disease

DOI: 10.1038/s44324-026-00137-x

Authors: Faiz Ur Rahman, Zong Wei

Institutions: Mayo Clinic in Arizona, Mayo Clinic

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590