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Pilot Randomized Trial of Patient-Directed vs Fixed-Antibiotic Duration in Acute Pyelonephritis

Year: 2026
Type: article
Abstract: ABSTRACT In this multi-center double-blind pilot randomized trial, patient-directed antibiotic duration after symptom resolution demonstrated similar sustained clinical resolution and adverse events compared to fixed-duration treatment among women with pyelonephritis. These findings support the feasibility of this strategy and justify a larger adequately powered randomized trial to evaluate efficacy and safety.
DOI: 10.1093/ofid/ofag705
Authors: Brett Faine, Gregory Moran, Anusha Krishnadasan, Anne Zepeski, Ruoyu Li, William Mower, Scott Evans, Jesus Torres, Frank LoVecchio, Nicholas Mohr, Vance Fowler, David Talan
Institutions: University of Iowa, University of Iowa Health Care, University of California, Los Angeles, Los Angeles Medical Center, Olive View-UCLA Medical Center, George Washington University, Valleywise Health, Duke Medical Center
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W7225107099
FWCI:
Cites: 13
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Related to: 10