Work

"Fire Follows Its Meridian": Site-Specific Inflammatory Memory and the Tissue Microenvironment in Recurrent Inflammation

Year: 2026

Type: preprint

Abstract: Review manuscript (v1.3.1). This record archives the manuscript and the complete submission package for "Fire Follows Its Meridian": Site-Specific Inflammatory Memory and the Tissue Microenvironment in Recurrent Inflammation. The manuscript operationalizes the Chinese clinical aphorism as site-addressed inflammatory recurrence (SAIR), proposes a five-layer framework (address, memory, residents, amplifiers, permission), treats the tissue microenvironment as the shared substrate of address and memory, and sets out ten falsifiable hypotheses (H1-H10) plus a staged research program. Public datasets analyzed: GEO GSE308379, GSE310145, GSE27887, GSE158432, GSE162054, GSE153760, and GSE250594. The archive includes the manuscript PDF, the full submission package ZIP, figures, reference verification, audit files, and portal copy. License: CC BY 4.0.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.23874546

Authors: Li, Jinzhe, Li, Juan, Li, Siwei, Yang, Zhongyi, Bian, Heng

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7225116876

Cites:

Cited by:

Related to: 10