A History of Cancer Research: Mouse Models of Cancer Genetics
Year: 2026
Type: preprint
Abstract: Studies of genetically engineered mice have contributed significantly to our understanding of tumor biology, and there are now countless mouse models of different human cancers. Breeding of mice for cancer research began more than 100 years ago. This provided early insights into cancer genetics, but it was the development of techniques for generating transgenic and knockout mice that transformed the field in the 1980s. The advent of CRISPR-Cas technology 30 years later made mouse models even easier to generate. In this excerpt from his forthcoming book on the history of cancer research, Joe Lipsick looks back at a century of advances in mouse cancer genetics, from the early pioneering work of Abbie Lanthrop to the Nobel-winning discoveries that now allow researchers to manipulate potential cancer genes in mice and explore their roles in tumorigenesis.
Author: Joseph Lipsick
Institution: Stanford University
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225117811