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O 4 -Thymidinyl functionalization to a solid support enables a versatile 3′-end oligonucleotide conjugation strategy

Year: 2026

Type: article

Abstract: A single support-bound precursor enables complementary routes to on-column 3′-modified DNA and RNA through pre-assembly amide coupling or post-assembly SPAAC, with further nucleobase functionalization possible during cleavage.

Source: RSC Advances

DOI: 10.1039/d6ra06451e

Authors: Nicholas G. Horton, Evan Zakaria, Dara V. Grebennikova, Derek K. O'Flaherty

Institution: University of Guelph

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,042

OpenAlex ID: W7225124249

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Cites: 37

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