Work

Novel triazolo[1,5]benzodiazepines as potent dual AChE/BChE inhibitors for Alzheimer's disease: synthesis, characterization, in vitro and in silico studies

Year: 2026

Type: article

Abstract: Targeting Alzheimer's disease, a cycloaddition route furnishes triazolo[1,5]benzodiazepines with potent, picomolar dual AChE/BChE inhibition, validated by X-ray, NMR, HRMS, and molecular docking.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d6md00416d

Authors: Marouane Ait Lahcen, Halil Şenol, Saad Zekri, Nastaran Sadeghian, Samir Hmaimou, Laura Chelazzi, Samuele Ciattini, Elena Zaballos-García, Parham Taslimi, Ismail Hdoufane, Driss Cherqaoui, Abdesselam Baouid, Mohamed Adardour

Institutions: Cadi Ayyad University, Bezmiâlem Vakıf Üniversitesi, Bartin University, University of Florence, Universitat de València

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7225127192

FWCI:

Cites: 59

Cited by:

Related to: 10