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Optimizing Preexposure Prophylaxis Adherence: Evaluating Point-of-Care Urine Tenofovir Testing and Tailored Counseling Among Young South African Women

Year: 2026
Type: article
Abstract: Among South African women using oral HIV preexposure prophylaxis, we compared a urine tenofovir point-of-care test with dried blood spot tenofovir diphosphate concentrations for recent vs longer-term adherence and assessed acceptability. The test demonstrated 76% accuracy, 100% sensitivity, and 69% specificity for high adherence (tenofovir diphosphate ≥700 fmol/punch) and was highly acceptable. Clinical Trials Registration: NCT04038060.
DOI: 10.1093/ofid/ofag612
Authors: Nicole Poovan, Jennifer Velloza, Nontokozo H Ndlovu, Allison Meisner, Cole Grabow, Monica Gandhi, Deborah Donnell, Sybil Hosek, Connie Celum, Sinead Delany-Moretlwe
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W7225146695
FWCI:
Cites: 18
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Related to: 10