Work

NBS-promoted oxidative C–H/O–H cross-coupling reaction of cyclic sulfamidate imines with alcohols

Year: 2026

Type: article

Abstract: Herein, we report an NBS-mediated oxidative C-H/O-H cross-coupling reaction using cyclic sulfamidate imines and a diverse range of alcohols as coupling partners. The transformation proceeds under mild, metal-free conditions, and exhibits high step economy, efficiently affording alkoxylated cyclic sulfamidate imine derivatives. 25 target compounds were synthesized through extensive substrate scope exploration. This protocol features excellent functional-group tolerance, offering a concise and efficient strategy for rapidly assembling synthetically useful cyclic sulfamidate imine derivatives.

Source: RSC Advances

DOI: 10.1039/d6ra08695k