Synthesis, in silico studies, and in vitro evaluation of novel isoindigo inhibitors targeting wild-type and D835Y mutant FLT3
Year: 2026
Type: article
Abstract: Fourteen isoindigos were synthesized; four inhibit FLT3 at nanomolar concentrations, 3 being the best dual inhibitor (243 nM wild-type, 121 nM D835Y), 8 the best on wild-type FLT3 at 180 nM, and both with stable binding over 1 µs of simulation.
Source: RSC Advances
DOI: 10.1039/d6ra08346c
Institutions: Petra University, Zarqa University, University of Jordan
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Funder: University of Petra
Award: G7600605011
OpenAlex ID: W7225167914