Work

Pulmonary Sarcoidosis Presenting as a Solitary Pulmonary Nodule With Probable Neurosarcoidosis: A Case Report

Year: 2026

Type: article

Abstract: A 51-year-old woman presented with a solitary pulmonary nodule, hilar and mediastinal lymphadenopathy and progressive sensory disturbances. FDG-PET demonstrated intense uptake in the pulmonary and hilar lesions, while spinal MRI showed thoracic cord enhancement. Lung cancer-associated paraneoplastic neurological syndrome was initially suspected. Biopsies of the endobronchial lesion and a mediastinal lymph node revealed noncaseating granulomas without malignancy. Ocular involvement and neurological findings supported pulmonary sarcoidosis with probable neurosarcoidosis. Corticosteroid therapy improved neurological symptoms. Long-term follow-up showed a stable pulmonary nodule and sustained neurological improvement. This case highlights the importance of tissue diagnosis and careful neurological assessment when pulmonary nodules and sensory disturbances suggest malignancy.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.70814