Work

Tetrazine-based bio-protection: reversible masking of cell surface thiols for orthogonal cellular chemistry

Year: 2026

Type: article

Abstract: nucleophilic aromatic substitution. Furthermore, we show that tetrazine-based protection preserves thiol-mediated cellular uptake capabilities, enabling precise temporal control over cell-surface thiol reactivity. This bio-protection strategy extends the toolkit of bioorthogonal chemistry to conditional masking of thiols, opening new avenues for dynamic cell-surface engineering, redox biology investigations, and controlled bioconjugation strategies in complex cellular environments.

Source: Chemical Science

DOI: 10.1039/d6sc04306b

Authors: Mingchen Sun, Katerina Gavriel, Chenxuan Wan, Jelte Schermer, Kevin Neumann, Daniela A. Wilson

Institution: Radboud University Nijmegen

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: European Commission, China Scholarship Council, H2020 European Research Council

OpenAlex ID: W7225182226

FWCI:

Cites: 34

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Related to: 10