Work

Identification of Potential Biomarkers for Ulcerative Colitis and Analysis of Immune Cell Infiltration: A Study Based on Data‐Independent Acquisition Proteomics and the GEO Public Database

Year: 2026

Type: article

Abstract: BACKGROUND: Ulcerative colitis (UC) is a challenging inflammatory bowel disease characterized by chronic inflammation of the colon's mucosal layer. Despite advances in medical research, UC lacks definitive diagnostic tests and targeted treatments. AIMS: This study aimed to preliminarily explore non-invasive potential biomarkers for UC based on proteomic analysis and publicly available GEO datasets. MATERIALS & METHODS: Bioinformatics analyses including ssGSEA for immune infiltration assessment, Spearman correlation analysis, ROC analysis, GSEA, and in silico drug prediction were performed. RESULTS: Four candidate hub genes (KRT17, TCEA3, ACP5, and ACOT13) were identified. ROC analysis demonstrated their potential clinical diagnostic value, and GSEA revealed their association with inflammatory pathways. A total of 28 potential compounds targeting these biomarkers were predicted, among which cinacalcet was selected as a priority candidate drug for further research. CONCLUSION: The identified hub genes have the potential to act as non-invasive candidate biomarkers for the early diagnosis of UC.

Source: PROTEOMICS - CLINICAL APPLICATIONS

DOI: 10.1002/prca.70061

Authors: Shuai Wang, Hualiang Deng, Dajuan Sun

Institutions: Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,430