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Greener and more sustainable access to 6,7-dimethoxy-2-aryl-4-aminoquinazolines via microwave-assisted chemo-selective synthesis in bio-renewable solvents

Year: 2026

Type: article

Abstract: , 80% reduction in reaction time (120 from 480-840 minutes) and achieving an Intrinsic atom economy of 82.2%, addressing seven out of the twelve Anastas-Warner green chemistry principles. This workflow underscores a scalable, solvent-efficient, metal-catalyzed route with reduced environmental impact.

Source: RSC Advances

DOI: 10.1039/d6ra08343a

Authors: Rhushikesh C. Deokar, Thrilokraj R, Nutan Sharma, Dhananjay Satav, Markus Obkircher, Sadaf Jamal Gilani, Saikat Sinha, Ramesh B. Dateer

Institutions: Jain University, Shree Guru Gobind Singh Tricentenary University, Princess Nourah bint Abdulrahman University

Language: English

Topic: Quinazolinone synthesis and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $1,042

Funders: Merck KGaA, Princess Nourah Bint Abdulrahman University

Award: G6351494049

OpenAlex ID: W7225196071

FWCI:

Cites: 37

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Related to: 10