Work

Bupropion-Induced Aseptic Meningitis: Postmarketing Safety Evaluation and Case Report

Year: 2026

Type: article

Abstract: The U.S. Food and Drug Administration (FDA) evaluated the association between bupropion and aseptic meningitis after detecting a safety signal during routine surveillance. Two cases of aseptic meningitis associated with bupropion were identified, including one exceedingly well-documented case that we assessed with a probable causal association with bupropion. The paucity of cases is striking given the long market duration and widespread utilization of bupropion-containing products. FDA required updates to the U.S. Prescribing Information for bupropion-containing products, as awareness of the rare, possible risk of aseptic meningitis with bupropion may prevent misdiagnosis or hospitalization.

Source: Psychopharmacology Bulletin

DOI: 10.64719/pb.21591

Authors: Joseph Cusimano, David Croteau, Jamie Ridley Klucken, Henry Appiah, Sheheryar Muhammad, Rajdeep Gill, Shamir Kalaria, Vicky Chan

Institution: United States Food and Drug Administration

Language: English

Topic: Pharmacovigilance and Adverse Drug Reactions

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7225203434

FWCI:

Cites: 12

Cited by:

Related to: 10