Work

The Toxicity of Macrolides Drug

Year: 2026

Type: article

Abstract: Toxic side effects from macrolide antibiotics include altered heart rhythm, liver damage, and upset stomach. Overview of Macrolide Toxicity • Heart risks: Medications that lengthen QT intervals, such as azithromycin, erythromycin, and clarithromycin, may result in harmful arrhythmias such torsades de pointes. • Liver damage: Oral macrolides, especially erythromycin estolate, can result in acute cholestatic hepatitis or moderate enzyme increases. • Problems with the stomach and intestines: Direct stimulation of gut motility often results in diarrhea, nausea, vomiting, and abdominal pain. • Effects on the nervous system: Rare cases of neurotoxicity (such as visual hallucinations) and ototoxicity (hearing abnormalities) have been documented, particularly in kidney disease patients.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.23909276

Authors: Muralinath E., Mr. Vonteru Munisekhar, Dr. P. Prabhavathi, K. Suparnalatha, M. Harshita, Dr. G. Rajeswari, Sravani Pragna K., Guruprasad M.

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7225205962

FWCI:

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Related to: 10