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Association Between Cholesterol‐ HDL ‐Glucose ( CHG ) Index and New‐Onset Hypertension Across Different Sex and Glycemic Status: A Longitudinal Study With 9‐Year Follow‐Up

Year: 2026
Type: article
Abstract: BACKGROUND: Hypertension is a major global public health issue, and the continuous search for new biomarkers to optimize risk stratification is crucial. This study aims to investigate the relationship between a novel metabolic disorder diagnostic tool-cholesterol, high-density lipoprotein, and glucose (CHG) index-and the incidence of hypertension in populations with different sexes and glycemic statuses. METHODS: This study utilized 9 years of follow-up data from the China Health and Retirement Longitudinal Study. Logistic regression models were employed to examine the association between the CHG index and new-onset hypertension across different sex and glycemic statuses. Additionally, the net reclassification improvement and integrated discrimination improvement indices were calculated to estimate the additional predictive value beyond the basic model. RESULTS: A total of 6555 participants were included in the study. A significant association between CHG index and new-onset hypertension was observed in the total, male, female, prediabetic, and diabetic populations, with adjusted OR (95% CI) of 1.16 (1.10-1.24), 1.23 (1.12-1.36), 1.12 (1.02-1.22), 1.14 (1.01-1.29), and 1.19 (1.03-1.36) respectively. Restricted Cubic Spline (RCS) analysis revealed a positive linear relationship between the CHG index and new-onset hypertension. The addition of either the CHG index or the Triglyceride-Glucose (TyG) index significantly improved the predictive performance of the basic model for hypertension. CONCLUSIONS: An elevated CHG index is significantly associated with new-onset hypertension.
DOI: 10.1002/edm2.70365
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,280
OpenAlex ID: W7225228936
FWCI:
Cites: 30
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Related to: 10