Work

Discontinuation of GLP-1RA Treatment Reinstates Binge-Like Eating and Drives Body Weight Past Pre-Treatment Levels in Mice

Year: 2026

Type: preprint

Abstract: We examined the impact of semaglutide treatment and discontinuation in a pre-clinical model for binge eating. Treatment reduced body weight and palatable food intake in mice with binge-like eating. Discontinuation reinstated binge-like eating and caused body weight to significantly exceed pre-treatment baseline, revealing specific binge-related risk when discontinuing GLP-1RAs.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.11.02.763781

Authors: Britny A. Hildebrandt, Susanne E. Ahmari

Institution: University of Pittsburgh

Language: English

Topic: Eating Disorders and Behaviors

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7225237539

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