Work

Complete Surgical Resection of Rare Solitary Anterior Mediastinal Metastasis From Ovarian Clear Cell Carcinoma

Year: 2026

Type: article

Abstract: Epithelial ovarian cancer typically spreads via transcoelomic dissemination and lymphatic pathways. Extra-abdominal metastases presenting as solitary anterior mediastinal lesions are rare. Ovarian clear cell carcinoma (CCC) is characterized by aggressive local behaviour but has a lower propensity for distant metastasis than serous carcinoma. Furthermore, it is less sensitive to platinum-based chemotherapy than other epithelial ovarian cancers. Here, we report a rare case of ovarian CCC with a solitary anterior mediastinal metastasis after primary surgery. A woman in her 50s had a 2.6-cm anterior mediastinal mass during postoperative surveillance. Considering progressive lesion enlargement and increased 18F-fluorodeoxyglucose uptake on positron emission tomography-computed tomography, complete surgical resection via median sternotomy was performed. Histopathological and immunohistochemical findings confirmed the presence of metastatic ovarian CCC. The patient remained disease-free for 6 months postoperatively. Complete surgical resection may represent an effective treatment option for isolated recurrence of chemoresistant histological subtypes.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.70809