Work

Neutral-pH pNZ Removal Enables Fully Aqueous Solid-Phase Synthesis of Linear and ε-Lys-Branched Peptides

Year: 2026

Type: article

Abstract: Aiming to emulate Nature by synthesizing peptides in water, we report pH ∼ 7 Na2S2O4/DIEA-induced pNZ removals as a means of enabling fully aqueous solid-phase peptide synthesis (SPPS). Furthermore, pNZ removal in water was applied to SPPS of ε-Lys-branched peptides and hybrid pNZ/Fmoc SPPS. Finally, combining our methods for SPPS in water with TFA-free resin cleavages opens the door to fully aqueous, PFAS-free approaches to a variety of complex peptides.

Source: ACS Omega

DOI: 10.1021/acsomega.6c08146

Authors: Jan Pawlas, Linnea Wahlqvist, Olov Nilsson, Linda M. Haugaard-Kedström

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Clean water and sanitation

Open Access status: gold

Estimated APC paid: $1,935

OpenAlex ID: W7225296692