Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective To investigate the clinical characteristics of patients with cirrhosis correlated with metabolic associated fatty liver disease (MAFLD). Methods A retrospective analysis was conducted on the general status, complications, comorbidities, and laboratory and imaging indicators of 186 patients with cirrhosis correlated with MAFLD. Depending on the type of data, count data were tested for normality using the Shapiro-wilk test. Normally distributed data were expressed as mean±standard deviation, while skewed distributions were presented as median and interquartile range . Count data were described by number of cases (n) and percentages (%) for statistical analysis. Results The age of the 186 patients with cirrhosis correlated with MAFLD was 61.49±11.56 years. Males accounted for 36.56% (68/186) and females for 63.44% (118/186). The prevalence of hypertension, diabetes, coronary heart disease, and dyslipidemia was 43.55% (81/186), 49.46% (92/186), 16.67% (31/186), and 82.26% (153/186), respectively. The overall complication occurrence rate was 83.87%, including hypersplenism in 103 cases (55.38%). Out of the 186 cases, 39 had no findings from the gastroscopy. Gastroscopy revealed esophagogastric varices in 100 cases (68.03%), ascites in 79 cases (42.47%), esophagogastric variceal rupture and bleeding in 20 cases (10.75%), portal vein thrombosis in 15 cases (8.06%), hepatic encephalopathy in 10 cases (5.38%), malignant liver tumors in 10 cases (5.38%), and extrahepatic tumors in 13 cases (6.99%). Colorectal malignancy was the most common in five cases (2.69%). Conclusion Cirrhosis correlated with MAFLD is more common in elderly women, while male patients have an earlier onset age. The vast majority of patients are overweight or obese, with relatively mild liver function impairment but more pronounced manifestations of portal hypertension.
Source: PubMed Central
Authors: Wang Huahua, Mao Yuting, Tang Li, Xu Qin, Sun Lihua
Language: Chinese
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225299854