Work

Neutralization and protective effectiveness of three XBB vaccines in older adults 12 months after booster

Year: 2026

Type: article

Abstract: The durability of neutralizing antibodies following updated COVID-19 vaccination is a key determinant for optimizing booster strategies in older adults, who remain at high risk for severe outcomes because of immunosenescence and waning immunity. We previously reported neutralizing responses in a prospective cohort of 90 older adults (≥65 years) at 6 months after boosting with trivalent (Tri-XBB.1.5), bivalent (Bi-Omi-XBB), or tetravalent (Tetra-XBB.1) protein vaccines. 1 In this extended follow-up to 12 months post-vaccination of the same cohort, we assessed neutralizing antibody persistence, decay kinetics, and protective effectiveness against SARS-CoV-2 infection. Detailed methods are provided in the Supplementary Materials.

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-026-03091-8

Authors: Yi-Man Cheng, Rui-Rui Chen, Mei Lu, Hai-Yan Yang, Bing-Dong Zhan, Mai-Juan Ma

Institutions: Academy of Military Medical Sciences, Zhengzhou University

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790