Work

Synthesis and preclinical evaluation of a novel 2-[ 18 F]fluoropyridine-bearing rhodamine for myocardial perfusion imaging with PET

Year: 2026

Type: article

Abstract: F]Rho6G-DEG-Py-F exhibited complete stability in rat and mouse serum over 120 min (37 °C). A radiometabolite assay in two rats showed differing metabolic profiles between sexes, but similar % intact tracer at 60 min (32-34%). Micro-PET imaging in rats demonstrated extended myocardial retention (SUV > 1.0 at 120 min), gradual liver washout, and high heart : liver ratios (3.7 in male, 2.5 in female at 120 min); however, similar experiments in mice revealed low heart uptake and rapid metabolism (SUV ∼ 0.3; heart : liver ratio = 1.0 at 120 min).

Source: RSC Advances

DOI: 10.1039/d6ra08884h

Authors: Maya Mahmood, Emily Murrell, Seniha Ozyuncu, Junchao Tong, Angelina Lui, James A. H. Inkster

Institutions: McMaster University, Centre for Addiction and Mental Health, University of Toronto

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042