Work

Genome-wide scan for transmission ratio distortion in trios from the Norwegian MoBa cohort rules out moderate distortion at common variants

Year: 2026

Type: article

Abstract: Transmission ratio distortion has been demonstrated in model organisms but is understudied in humans. We conduct single- and multi-locus transmission disequilibrium tests to detect transmission ratio distortion in up to 43,829 parent–offspring trios from the Norwegian Mother, Father and Child Cohort Study. We find little evidence for moderate to high levels of transmission ratio distortion at common variants. However, our multi-locus analyses implicate genes involved in meiosis, fertility, and prenatal development.

Source: Genome biology

DOI: 10.1186/s13059-026-04333-2

Authors: Shannon D’Urso, Elizabeth C. Corfield, Laurie J. Hannigan, Ole A. Andreassen, Astanand Jugessur, Kasper Munch, George Davey Smith, Gibran Hemani, Liang-Dar Hwang, Gunn-Helen Moen, Alexandra Havdahl, David M. Evans

Institutions: The University of Queensland, Aarhus University, Mater Research, Institute for Molecular Bioscience, Norwegian Institute of Public Health, University of Bristol, Lovisenberg Diakonale Sykehus, MRC Integrative Epidemiology Unit, Oslo University Hospital, University of Oslo, University of Bergen, Norwegian University of Science and Technology

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,490

Funders: NordForsk, Australian Research Council

OpenAlex ID: W7225309578

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