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A Disseminated Adverse Drug Reaction in a Child in Response to Beta‐Lactam Patch Testing

Year: 2026

Type: article

Abstract: Patch testing is considered safe in the evaluation of selected non-immediate drug hypersensitivity reactions in both children and adults. This report describes a 2-year-7-month-old boy whose index reaction to amoxicillin-clavulanate was a non-severe but widespread maculopapular eruption that intensified with continued dosing. Because of its extent and progression, patch testing was performed before the planned drug provocation test. A disseminated maculopapular eruption developed after patch testing, with a strong positive (2+) reaction at 48 h. This case highlights that generalized cutaneous reactions may rarely occur after patch testing, even when the initial reaction is non-severe.

Source: Pediatric Dermatology

DOI: 10.1111/pde.70399

Authors: Cansu Türkay, Sezin Aydemir, Leman Tuba Karakurt, Mustafa Arga

Institutions: Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi, Istanbul Medeniyet University

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7225316689

FWCI:

Cites: 15

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Related to: 10