Tyrosine kinase inhibitors are associated with reduced AML transformation in systemic mastocytosis with myeloid neoplasm
Year: 2026
Type: article
Study design: Observational Study
Abstract: In an international registry analysis of 201 patients with SM-AHN, KIT D816V-selective TKI exposure was associated with longer overall survival (37.9 vs 17.8 months; P <.001) and lower 36-month incidence of acute myeloid leukemia transformation (5.9% vs 27.1%; P <.001).
Source: Blood
Authors: Olivier Hermine, Orianne Debeaupuis, Gandhi-Laurent Damaj, Johannes Lübke, Juliana Schwaab, Marc Heizmann, Frank Siebenhaar, Polina Pyatilova, Nicole Nojarov, Marek Niedoszytko, Aleksandra Górska, Mattias Mattsson, Khalid Shoumariyeh, Stephan de Bra, Friederike Wortmann, Nikolas von Bubnoff, Horia Bumbea, Delia Soare, Chiara Elena, Judit Varkonyi, Anna Belloni Fortina, Simge Erdem, Knut Brockow, Tobias Franz, Jens P. Panse, Deborah Christen, Christine Breynaert, Akif Selim Yavuz, Luca Malcovati, Michael Doubek, Vito Sabato, Ilaria Tanasi, Massimiliano Bonifacio, Karin Hartmann, Axel Rüfer, Mariarita Sciumè, Valentina Bellani, Irena Angelova-Fischer, Alex Stefan, Massimo Triggiani, Roberta Parente, Saskia K Klein, Michael Makris, Sotirios G. Papageorgiou, Paul van Daele, Ingunn Dybedal, Daniel Baffoe, Theo Gulen, Madlen Jentzsch, Olivier Lortholary, Maël Heiblig, Cristina Bulai Livideanu, Stéphane Barete, Clément Gourguechon, Sophie Dimicoli-Salazar, Olivier Tournilhac, Laurent Frenzel, Michel Arock, Andrzej Mital, Johannes N. Woltsche, Hanneke C. Kluin-Nelemans, Hanneke N.G. Oude Elberink, Jason Gotlib, Martina Sperr, Andreas Reiter, Peter Valent, Wolfgang R. Sperr, Julien Rossignol
Institutions: Hôpital Necker-Enfants Malades, Université Paris Cité, Assistance Publique – Hôpitaux de Paris, Institut des Maladies Génétiques Imagine, Heidelberg University, University Medical Centre Mannheim, Kantonsspital Aarau, Charité – Universitätsmedizin Berlin, University Clinical Centre, Gdańsk Medical University, Uppsala University Hospital, University of Freiburg, University Medical Center Freiburg, University Hospital Schleswig-Holstein, University of Lübeck, Clinical Emergency Hospital Bucharest, Bucharest Emergency University Hospital, Policlinico San Matteo Fondazione, Semmelweis University, University of Padua, Azienda Ospedale - Università Padova, Istanbul University, Technical University of Munich, Universitair Ziekenhuis Leuven, KU Leuven, Masaryk University, University Hospital Brno, University of Antwerp, Antwerp University Hospital, Azienda Ospedaliera Universitaria Integrata Verona, University of Basel, University Hospital of Basel, Luzerner Kantonsspital, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, ASST Melegnano e della Martesana, Kepler Universitätsklinikum, Johannes Kepler University of Linz, University of Salerno, University Medical Center Groningen, University of Groningen, Erasmus MC, Oslo University Hospital, Karolinska University Hospital, University Hospital Leipzig, Inserm, Hôpital Cochin, Hôpital Lyon Sud, Centre Hospitalier Universitaire de Toulouse, Sorbonne Université, Centre Hospitalier Universitaire Amiens-Picardie, Centre Hospitalier Universitaire de Bordeaux, Centre Hospitalier Universitaire de Clermont-Ferrand, Pitié-Salpêtrière Hospital, Medical University of Graz, Stanford Medicine, Stanford Cancer Institute, Stanford University, Medical University of Vienna
Language: English
Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,500
OpenAlex ID: W7225317067