Year: 2026
Type: article
Abstract: Metabolic-associated fatty liver disease (MAFLD) is showing a high prevalence trend worldwide, and its complication, hepatic osteopathy (HO), significantly increases the patients' risk of fractures and reduces the quality of life. The osteoprotegerin (OPG )/receptor activator of nuclear factor κB ligand (RANKL) pathway plays an important role in the occurrence and development of MAFLD-HO. The article reviews the role and regulatory mechanism of the OPG/RANKL pathway in MAFLD-HO disease burden, as well as potential therapeutic intervention strategies targeting the OPG/RANKL axis and their application prospects in MAFLD-HO.
Source: PubMed Central
Authors: Qin Xiangxin, Wu Tianhao, Sun Chao, Nan Yuemin
Language: Chinese
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Award: G4333686261
OpenAlex ID: W7225317808