Work

Mechanosensing in mesenchymal stem cells: signaling, memory, and translation

Year: 2026

Type: article

Abstract: Mechanical forces are key determinants of mesenchymal stem cell (MSC) functional homeostasis, which underpins repair and regeneration across multiple organs and tissues. Aging and inflammation disrupt MSC homeostasis by altering cellular mechanosensing and mechanotransduction. Safeguarding MSC homeostasis is therefore clinically relevant for regenerative medicine. This review summarizes how tensile strain, compressive loading, and fluid shear stress regulate MSC functional homeostasis in a parameter- and context-dependent manner, evaluates the evidence linking mechanosensors to downstream signaling and mechanical memory, and outlines key limitations and translational challenges.

Source: Stem Cell Research & Therapy

DOI: 10.1186/s13287-026-05381-y

Authors: Ruotong Lian, Xiaoyu Li, Chen Zhang

Institution: Capital Medical University

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190